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KMID : 0363620060270020155
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Journal of Korean Oriental Medicine
2006 Volume.27 No. 2 p.155 ~ p.170
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Hypoglycemic, Hepatoprotective, and Nephroprotective Effects of - ’Saengjinyanghyul-tang(Sh={e}ngj={i}nyv{a}ngxu`{e}-t={a}ng)’ - in Streptozotocin-Induced Diabetic SD Rats
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Kwak Min-A
Kim Min-Soo
Byun Joon-Seok
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Abstract
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Objectives : This study aimed to evaluate the hypoglycemic, hepatoprotective, and nephroprotective effects of ’’Saengjinyanghyul-tang(Sh={e}ngj={i}nyv{a}ngxu`{e}-t={a}ng : SJYHT)’’ in streptozotocin (STZ)-induced diabetic SD rat model.
Methods : SJYHT extracts were once a day dosed for 28 days at a dosage 1000, 500, and 250mg/kg/5ml from 25 days after STZ-dosing, and the changes on blood glucose levels, liver and kidney weight, serum AST, ALT, BUN and creatinine levels were observed with histological changes on the liver and kidney.
Results :Increased blood glucose levels, and diabetic hepatopathy & nephropathy including increased serum AST, ALT, BUN and creatinine levels, histological changes after STZ-dosing were dose-dependently reduced by SJYHT extract-dosing.
Conclusions :`’SJYHT’’ water extracts have favorable hypoglycemic, hepatoprotective, and nephroprotective effects on the STZ-induced diabetic SD rats. Therefore, it is expected that ’’SJYHT’’ has potential for use in the management of diabetes and diabetic complications.
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KEYWORD
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Saengjinyanghyul-tang(Sh={e}ngj={i}nyv{a}ngxu`{e}-t={a}ng), diabetes, diabetic hepatopathy, diabetic nephropathy
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